Regenerative Medicine Utrecht

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The role of the Foxp1 transcription factors in embryonic neural stem cell differentiation

Multidisciplinary research between three groups within Regenerative Medicine Utrecht has led to a new publication in Stem Cell Reports. In the publication the groups of Coffer, Pasterkamp and Nijboer characterize the role of the Foxp1 transcription factors in embryonic neural stem cell differentiation.  Mutations in FOXP1 have been linked to neurodevelopmental disorders including intellectual disability and autism; however, the underlying molecular mechanisms remain ill-defined. In this publications the researchers demonstrate with RNA and chromatin immunoprecipitation sequencing that FOXP1 directly regulates genes controlling neurogenesis. Furthermore they show that FOXP1 is expressed in embryonic neural stem cells (NSCs), and modulation of FOXP1 expression affects both neuron and astrocyte differentiation.

Open access, read the article here.