Regenerative Medicine Utrecht

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Jesper Hjortnaes receives a Dr. Dekkergrant for research on personalised heart tissues

Jesper Hjortnaes receives a Dr. Dekkergrant from the Dutch Heart Foundation for research on ‘heart-on-a-chip’. With this grant he will create personalized heart tissues of patients with heartfailure in the laboratory. 

‘Modern heart surgery is in an age of rediscovery and innovation’, says Jesper Hjortnaes, AIOS Cardiothoracal surgery and Postdoc in the Regenerative Medicine Center Utrecht. ‘An important part of this is the upcoming of tissue engineering.This means the development to create personalized heart tissue of patients in the lab, not only to replace diseased tissue, but also to gain better insight into mechanisms of disease and cure. Our interest mainly lies in heartfailure and its treatment’.

 ‘Heart-on-a-chip’

With the Dr. Dekkergrant of the Dutch Heart Foundation we will create personalized heart tissues of patients with heartfailure in the lab. We will use the ‘organ-on-a-chip’ technology, that provides the opportunity to engineer micro-scale heart tissue with the size of a computerchip. We call these tissues heart-on-a-chip’.

Hearttissues

‘These ‘hearts-on-a-chip’ are unique in the possibility to expose the patient specific tissues to a range of circumstances and explore mechanisms of disease and cure. We will not only gain insight in different mechanisms of heartfailure, but also use the patient specific tissues to study the effect of existing and new therapies. All of this will be done in a human model of heart tissue, but outside of the body in a laboratory.’